雷蓓蕾

作者: 来源: 发布日期:2018-06-21 浏览次数:

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雷蓓蕾,女,1984年生,博士,副教授,硕士研究生导师。

2006年本科毕业于兰州大学化学化工学院;2011年6月博士毕业于兰州大学化学化工学院;2009年9月至2011年4月在美国肯塔基大学药学院联合培养。2011年7月进入pg电子游戏试玩网站官网平台pg电子游戏试玩网站官网平台工作。中国化学会会员。

开设课程:

承担本科生《生物信息学》、《生物信息学综合实验》,参与研究生《生物信息学研究进展》课程教学工作。

研究方向:

植物激素类似物的计算机辅助分子设计;

化学小分子对植物生长及逆境响应的调控。

主持的科研项目:

国家自然科学基金青年基金,基于靶标BRI1的新型油菜素内酯受体激动剂的合理设计(21302153,2014-2016);

陕西省自然科学基金青年项目,油菜素甾醇类植物激素类似物的虚拟筛选研究及生物活性评价(2017JQ3003,2017-2018);

中央高校基本科研业务费青年培育项目,基于药效团的BRI1激动剂的虚拟筛选及活性评价(2015);

发表论文:

Lei, B. L., Heng, NJ, Dang, XX, Liu, J. Y., Yao, X. J and Zhang CL*. Structure based in silico identification of potentially non-steroidal brassinosteroids mimics. Molecular Biosystems, 2017. 13(7): p.1364-1369.

Lei, B. L.*, Liu, J. Y., and Yao, X. J. Unveiling the molecular mechanism of brassinosteroids: Insights from structure-based molecular modeling studies . Steroids, 2015. 104: p. 111-117.

Lei, B. L.*, Li, J. Z., and Yao, X. J., A Novel Strategy of Structural Similarity Based Consensus Modeling. Molecular Informatics, 2013. 32(7): p. 599-608.

Lei, B. L., Adel, H. and Zhan, C.-G.*, Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations. Theoretical Chemistry Accounts, 2012. 131(4): p. 1203-1213.

Wei, D. H., Lei, B. L., Tang M. S., and Zhan C.-G.*, Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin , Journal of the American Chemical Society, 2012. 134(25): p. 10436-10450.

Lei, B. L., Hameed, Mdma, Hamza, A., Wehenkel, M., Muzyka, J. L., Yao, X. J., Kim, K. B., and Zhan, C. G.*, Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations. Journal of Physical Chemistry B, 2010. 114(38): p. 12333-12339.

Lei, B. L., Ma, Y. M., Li, J. Z., Liu, H. X., Yao, X. J.*, and Gramatica, P., Prediction of the adsorption capability onto activated carbon of a large data set of chemicals by local lazy regression method. Atmospheric Environment, 2010. 44(25): p. 2954-2960.

Lei, B. L., Li, J. Z., Lu, J., Du, J., Liu, H. X., and Yao, X. J.*, Rational Prediction of the Herbicidal Activities of Novel Protoporphyrinogen Oxidase Inhibitors by Quantitative Structure-Activity Relationship Model Based on Docking-Guided Active Conformation. Journal of Agricultural and Food Chemistry, 2009. 57(20): p. 9593-9598.

Lei, B. L., Li, S. Y., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Novel approaches for retention time prediction of oligonucleotides in ion-pair reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 2009. 1216(20): p. 4434-4439.

Lei, B. L., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Global, local and novel consensus quantitative structure-activity relationship studies of 4-(Phenylaminomethylene) isoquinoline-1, 3 (2H, 4H)-diones as potent inhibitors of the cyclin-dependent kinase 4. Analytica Chimica Acta, 2009. 644(1-2): p. 17-24.

Lei, B. L., Du, J., Li, S. Y., Liu, H. X., Ren, Y. Y., and Yao, X. J.*, Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors. Journal of Computer-Aided Molecular Design, 2008. 22(10): p. 711-725.

Lei, B. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Accurate prediction of aquatic toxicity of aromatic compounds based on Genetic Algorithm and Least Squares Support Vector Machines. Qsar & Combinatorial Science, 2008. 27(7): p. 850-865.

联系方式:

通讯地址:陕西杨凌,pg电子游戏试玩网站官网平台pg电子游戏试玩网站官网平台

邮政编码:712100

E-mail: leibl@nwsuaf.edu.cn